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GoodRx Health. Several medications are available to treat erectile dysfunction (ED). But Viagra (sildenafil) is likely the one you ve heard about most. It was the first phosphodiesterase-5 inhibitor to be FDA approved for ED, and it s gone on to become one of the most recognizable medications on the market. drugs similar to viagra Generic Viagra treats ED and works the same way as the brand-name version. It s generally recommended to take one 50 mg by mouth 1 hour before sexual activity. Like all medications, generic Viagra has side effects you should be aware of. If you experience an erection lasting longer than 4 hours, seek emergency medical care right away. Viagra is in a class of medicines known as phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis. The U.S. Food and Drug Administration (FDA) approved this medicine in