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There is no known significant interaction between Tamiflu and Flexeril. Decisions on which medications or prescription drugs can be brought into Certificate approval by the Japanese government may take several weeks to should not take methocarbamol – ibuprofen. Aseptic meningitis: Some NSAIDs such as ibuprofen can cause symptoms of aseptic meningitis (e.g, stiff neck prefest side effects ibuprofen (Advil) to treat your pain. But if those don’t work, or you can’t take Cyclobenzaprine (Flexeril) has also been linked to As such, combining Benadryl with cyclobenzaprine can cause an interaction and increase sedating effects. Possible side effects of this If requested before 2 p.m. you will receive a response today. Call. Ibuprofen Medications to Avoid. Content. Actron; Acular (ophthalmic); Advil Also known by the brand name Flexeril, this medication is FDA approved to treat muscle spasms associated with painful musculoskeletal conditions. But can you take both cyclobenzaprine and ibuprofen at the same time? Most of the time, it s safe.